The Utility of Platelet Rich Plasma in Hair Loss

Early Phase 1CompletedNCT03376581

University of California, Irvine30 enrolled

Overview

Platelet rich plasma (PRP) is an autologous preparation of human plasma with high concentration of platelets. Platelets release numerous growth factors, which stimulate cell proliferation and differentiation. The purpose of this research is to investigate the potential of PRP injection for treatment of hair loss. Clinical outcomes will be assessed by noninvasive techniques including dermoscopy, multiphoton microscopy, optical coherence tomography, optical Doppler tomography and multispectral imaging.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Androgenetic Alopecia

Interventions

Platelet rich plasmaPROCEDURE

Blood drawn from each participant will be spun down to separate platelets. Platelets will be injected into that patient's scalp.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 95 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Over 18 years of age * Ability to understand and carry out instructions * Diagnosed with alopecia Exclusion Criteria: * Inability to understand and.or carry out instructions * Pregnant women * Use of any topical medication (such as minoxidil or any other solution for hair growth), oral medication (finasteride, dutasteride, or antiandrogens), laser therapy, or chemotherapy, within the preceding 4 weeks. * Personal medical history of bleeding disorders * Personal medical history of platelet dysfunction syndrome * Anti-coagulation therapy or nonsteroidal anti-inflammatory drugs in the last 1 week.

Locations (1)

University of California, Irvine, Department of Dermatology, Dermatology Clinical Research Center, Hewitt Hall

Irvine, California, United States

Outcomes

Primary Outcomes

Hair density to measure the efficacy of treatment

Time frame: 6 months

Secondary Outcomes

Hair count (number of hairs/0.65 cm2)

Time frame: 6 months

Terminal hair density

Time frame: 6 months

Anagen hair percentage

Time frame: 6 months

Telogen hair percentage

Time frame: 6 months

Anagen/telogen ratio

Time frame: After 3 and 6 months

Changes in hair structure, diameter, and blood flow

As measured by optical coherence tomography

Time frame: 6 months

Data from ClinicalTrials.gov

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