Application of n-3 Fatty to Patient of Jaundice

Huazhong University of Science and Technology106 enrolled

Overview

The safety and efficacy of ω-3 fatty acid in patients with obstructive jaundice is not known. This study provided evidences that ω-3 fatty acid-based parenteral nutrition improved postoperative recovery for patients with obstructive jaundice.

Lipid emulsion enriched in n-3 fatty acid (FA) has been reported to improve postoperative recovery for surgical patients with biliary tract disease, and to improve laboratory and clinical outcomes. The role of it for postoperative patients with jaundice is not clear yet. The object of this research was to evaluate the safety and efficacy of n-3 fatty acid-based parenteral nutrition (PN) for patients with jaundice following Surgical procedure. This cohort study was a pragmatic, retrospective, single center, matched, clinical trial from May 2014 to June 2017.

Study Type

OBSERVATIONAL

Enrollment

106

Conditions

Obstructive Jaundice Surgical Procedure, Unspecified

Interventions

trail cohortDRUG

Drug: Omega-3 Fatty Acid-Based Parenteral Nutrition Glucose, lipid emulsion, amino acids, fat-and water-soluble vitamins as well as electrolytes were compounded in an "All-In-One" manner. 20% Structolipid and 10% Omegaven (ω-3 fatty acid \[FA\] mainly; Fresenius-Kabi, Germany) were applied to the trial group, but only Structolipid (ω-6 FA mainly) to the control group for 5 consecutive days postoperatively.

control cohortDRUG

Drug: Structolipid Glucose, lipid emulsion, amino acids, fat-and water-soluble vitamins as well as electrolytes were compounded in an "All-In-One" manner. 20% Structolipid and 10% Omegaven (ω-3 FA mainly; Fresenius-Kabi, Germany) were applied to the trial group, but only Structolipid (ω-6 FA mainly) to the control group for 5 consecutive days postoperatively.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * the diagnosis of obstructive jaundice must be clear (serum toal bilirubin \>51.3umol/L \& Imaging evidence), and the obstruction is located in the extrahepatic bile duct; * Duration of Jaundice is less than 2 weeks; * Nutritional support is needed * Nutritional support was administrated during the perioperative period; * Drainage treatment is effective. Exclusion Criteria: * Contraindication for surgical procedure, including Child-Pugh Classification C, severe hemorrhagic disorders, gastrointestinal hemorrhage, acute infectious disease, active phase of chronic hepatitis B \& C, severe circulatory disease, renal failure pre -operation, and other unknown cause; * Abandon treatment; * Length of stay in hospital \<5 day; * Nutrition support \<5 day; * Conservative treatment; * Incomplete data; * Allergic reactions against PN.

Locations (1)

Hepatic Surgery Center of Tongji Hospital

Wuhan, Hubei, China

Outcomes

Primary Outcomes

Safety (complications)

postoperative complications

Time frame: postoperative period（1 month ）

velocity of the serum total bilirubin clearance

the velocity of the serum TBIL clearance, which was calculated according to formula behind: (formal TB -TB of current) /time interval

Time frame: postoperative period（1 month ）

Secondary Outcomes

kidney function

blood test for GFR and creatinine

Time frame: postoperative period（1 month ）

Data from ClinicalTrials.gov

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