The purpose is to evaluate the effectiveness and safety profile of zolmitriptan by Sublingual administration for the acute treatment of Cluster headache.
Cluster headache is a primary neurological disorder characterized by intensive attacks and severe sharp headache, can cause a range of symptoms such as conjunctival congestion, runny nose, miosis, forehead sweat. The disability resulting from cluster headache can be severe imposing a considerable health burden upon the sufferer and society. The purpose of this study, using oral zolmitriptan as the control, is to evaluate the effectiveness and safety of zolmitriptan by sublingual administration for the acute treatment of cluster headache. Patients are asked to maintain a headache diary throughout the treatment period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
71
Experimental group
Active group
The points-reducing of visual analogue scale several minutes after sublingual zolmitriptan tablet
The difference of the percentage of the headache attacks whose visual analogue scale points reduce from 7-10 to 0-3 5, 10, 15 minutes after administration between sublingual and oral zolmitriptan tablet
Time frame: 5, 10, 15 minutes after administration
The percentage of side effects;
The difference of the percentage of side effects in 3 hours after the administration between sublingual and oral zolmitriptan tablet
Time frame: 3 hours
The percentage of discontinued the drug
The percentage of discontinued the drug because of side effects
Time frame: 3 days
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