Evaluating the safety and efficacy of EXPAREL (Liposomal Bupivacaine ) for pain control in patients undergoing scheduled cesarean section by giving it either as infiltration in Transversus Abdominis Plane after finishing the procedure or through wound infiltration into the fascia prior to closure of skin
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
University of Minnesota
Minneapolis, Minnesota, United States
Total opioid consumption
Total opioid medication use by patient after having cesarean section
Time frame: 72 hours
Time to first rescue opioid pain medication
Time till the patient asks for opioid medication for breakthrough pain
Time frame: 72 hours
Percentage of opioid-free subjects
Percentage of patients didn't require any opioid medications after the cesarean section
Time frame: 24,48, and 72 hours
Patient's satisfaction
Patient's satisfaction questionnaire with pain control
Time frame: through 72 hours post-op or at discharge
VAS (visual analogue scale) pain scores
pain level assessment using visual assessment pain score which ranges from zero for no pain to 10 intolerable pain
Time frame: at 6, 12, 18, 24, 30, 36, 42, 48, and 72 hours after surgery
Number of participants with EXPAREL related adverse events
side effects of EXPAREL
Time frame: through day 14 post-op
Allergic reactions attributable to local anesthetic use
Such as allergies, rash etc...
Time frame: through day14 post-op
Wound complications
cesarean section wound complications like infection, hematoma, and dehiscence
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Time frame: through day 14 post-op