Modifiers of Tenofovir in the Female Genital Tract

Inclusion Criteria: * Female, or transgender female with a cervix, aged 18-35 years old * HIV-positive * Stable on antiretroviral regimen containing TDF for at least 2 weeks at time of enrollment. * Virally suppressed (HIV-RNA copies \<50 copies/mL) for at least 6 months at time of enrollment. * Willing to refrain from vaginal intercourse and use of vaginal devices such as douches and sex toys within 72 hours of the biopsy visit. * Willing and able to give signed informed consent. Exclusion Criteria: * Currently pregnant or previous pregnancy within 3 months of enrollment * Currently breast feeding * Symptomatic vaginal infection within 2 weeks prior to enrollment * Unexplained, undiagnosed abnormal bleeding per vagina, bleeding per vagina during or following vaginal intercourse, or gynecologic surgery within 90 days prior to enrollment * History of vulvar/vaginal/ cervical dysplasia, neoplasia or cancer, atypical squamous cells of undetermined significance, condyloma, or human papilloma virus (HPV) in the past year * Use of oral and/or vaginal preparations of antibiotic or antifungal medications within 30 days prior to the enrollment visit