Spermidine Intake and All-cause Mortality

Medical University Innsbruck829 enrolled

Overview

This study seeks to test the potential association between spermidine content in diet and mortality in humans.

This prospective community-based cohort study includes 829 participants aged 45-84 years, 49.9% of which are male. Diet is assessed by repeated dietician-administered validated food-frequency questionnaires (2540 assessments) in 1995, 2000, 2005, and 2010. Nutrient intakes including spermidine are calculated using USDA standard databases. Clinical events (all-cause mortality and cause-specific mortality) are recorded from 1995 to 2015. The primary endpoint of all-cause mortality is related to the exposure of long-term average spermidine intake by Cox proportional hazards models with time-varying covariates. Additional analyses employ the Fine and Gray proportional subdistribution hazards model and flexible Royston-Parmar spline-based models. Comprehensive sensitivity analyses are performed to guard against potential biases associated with nutritional epidemiology.

Study Type

OBSERVATIONAL

Enrollment

829

Conditions

Healthy Diet Mortality

Interventions

Spermidine content of natural dietOTHER

The exposure consists in the long-term average dietary intake of the polyamine spermidine

Eligibility

Sex: ALLMin age: 45 YearsMax age: 84 Years

Medical Language ↔ Plain English

Inclusion Criteria: Resident of Bruneck aged 40-79 years in 1990, age- and sex-stratified random sample. Exclusion Criteria: None.

Outcomes

Primary Outcomes

All-cause mortality

Death due to any cause

Time frame: 1995-2015

Secondary Outcomes

Cause-specific mortalities

Death due to cardiovascular disease, cancer, or other causes

Time frame: 1995-2015

Data from ClinicalTrials.gov

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