AO Multicenter Intervention Trial for Prevention of Surgical Site Infection

Inclusion Criteria: * • Age \> 18 years * Recent fracture (\< 10 days) located in femur, tibia or humerus * Any type of open or closed fracture * Produced by high or low energy trauma * Primary fracture treatment with surgery and use of any of the following: * Intramedullary or extramedullary devices including cases in which a temporary external fixator is used * Joint replacement * Informed consent obtained (if required by local EC/IRB), i.e.: * Ability to understand the content of the patient information/ICF * Willingness and ability to participate in the clinical investigation according to the Clinical Investigation Plan (CIP) * Signed and dated EC/IRB approved written informed consent Exclusion Criteria: * Pathologic fracture secondary to tumors, infection or cysts * Patients with an underlying chronic, bone and joint infection or prior history of a bone and joint infection * Refracture and non-union * Peri-implant fractures * Patients with terminal illness * Pregnancy or women planning to conceive within the study period * Prisoner * Participation in any other medical device or medicinal product study within the previous month that could influence the results of the present study