The Effect of Exercise on Gut Microbiota in Type 2 Diabetic Patients

Inclusion Criteria: * Subjects must meet the criteria for diabetes type 2 (a random blood sugar of \> 11.1 mmol/L and/or a fasting blood sugar lever of \>7.0 mmol/L and/or a blood sugar of \>11.1 mmol/L two hours after an oral glucose tolerance test and/or an HbA1c level of \>47 mmol/mol). * Male or female (post-menopausal) * Age above 45 years and below 70 years * BMI \>30 kg/m2 * HbA1c \< 80 mmol/mol or \< 8,6% Subjects must use metformin * Stable medication use * Stable tension regulation (with or without medication) * Subjects should be able to give informed consent Exclusion Criteria: * A history of cardiovascular event (Cerebrovascular event, myocardial infarction or pacemaker implantation) * Severe-very severe lung emphysema (GOLD stage III-IV) * Use of any antibiotics or proton pump inhibitor (PPI) in the past three months * Use of any other antidiabetic medication besides metformin (e.g. SU-derivates, insulin) * Use of a platelet inhibitor or cumarin derivate during * Subjects participated in a lifestyle programme in the past 6 months (diet or exercise)