Patients with type 2 diabetes and non-alcoholic fatty liver disease will be enrolled. According to a parallel design, the participants will be randomized to a Portfolio diet or a monounsaturated fatty acid (MUFA)-rich diet (used as control) for 8 weeks. At the beginning and at the end of the trial, the participants will undergo a MRI spectroscopy to evaluate fatty liver content. Moreover, the participants will undergo a test meal resembling the nutritional composition of the assigned diet to evaluate fasting and postprandial metabolic response.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
49
Medium-term (8 weeks ) nutritional intervention
Medium-term (8 weeks ) nutritional intervention used as control
Department of Clinical Medicine and Surgery
Naples, Italy
Liver fat content
MRI spectroscopy
Time frame: Change from Baseline after 8 weeks
Liver functionality
Liver enzymes
Time frame: Change from Baseline after 8 weeks
Blood pressure
Time frame: Change from Baseline after 8 weeks
Endothelial function
Flow-mediated dilation
Time frame: Change from Baseline after 8 weeks
Liver fibrosis
Transient Elastography
Time frame: Change from Baseline after 8 weeks
Biochemical parameters
glucose homeostasis (glucose)
Time frame: Change from Baseline after 8 weeks
Body composition
bioimpedance analyses (BIA)
Time frame: Change from Baseline after 8 weeks
lipids
Time frame: Change from Baseline after 8 weeks
subclinical inflammation
elisa
Time frame: Change from Baseline after 8 weeks
oxidative stress
urinary isoprostanes
Time frame: Change from Baseline after 8 weeks
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Biochemical parameters
glucose homeostasis (HbA1c)
Time frame: Change from Baseline after 8 weeks
Biochemical parameters
glucose homeostasis (Insulin)
Time frame: Change from Baseline after 8 weeks