The primary objective of this study is to investigate the effects of wakame and spirulina consumption on intestinal cholesterol absorption.
Objectives: Secondary objectives are to investigate the effects of wakame and spirulina consumption on fasting markers for lipid metabolism, glucose metabolism and blood pressure. Study design: This study is a double-blinded, randomized, placebo-controlled, crossover intervention trial consisting of three intervention periods of 17 days each, separated by a minimum washout period of 14 days. Study population: The study population will consist of 37 healthy, non-hypercholesterolemic men and women aged between 18 and 70 years. Intervention: All subjects will receive wakame, spirulina and placebo capsules in randomized order. Subjects will be asked to consume 12 capsules per day for 17 days, which is equal to 4.8 grams of wakame or spirulina a day.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
36
Maastricht University Medical Center
Maastricht, Limburg, Netherlands
Markers for intestinal cholesterol absorption
Serum cholesterol-standardized campesterol concentrations will be measured as a marker for intestinal cholesterol absorption
Time frame: Difference in outcomes between interventions and control at 17 days
Lipids
Several markers for fasting lipid metabolism, including total cholesterol, LDL cholesterol and HDL cholesterol, will be measured in blood samples
Time frame: Difference in outcomes between interventions and control at 17 days
Markers for cholesterol synthesis
Serum cholesterol-standardized lathosterol and desmosterol concentrations will be measured as a markers for cholesterol synthesis
Time frame: Difference in outcomes between interventions and control at 17 days
Glucose concentrations
Fasting plasma glucose concentrations will be determined
Time frame: Difference in outcomes between interventions and control at 17 days
Blood pressure
Systolic and diastolic blood pressure will be determined
Time frame: Difference in outcomes between interventions and control at 17 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.