The Effect of Sugammadex Given Based on Ideal, Actual or Adjusted Body Weight on Reversal of Rocuronium.

Ain Shams University60 enrolled

Overview

The aim of this study is compare the reversal of rocuronium induced neuromuscular blockade in morbidly obese patients using three doses of sugammadex; based on ideal body weight, adjusted body weight, and actual body weight. Reversal Time: time from administration of Sugammadex to train of four (TOF) ratio ≥ 0.9 will be used as primary outcome. Time need for extubation (time from administration of sugammadex to extubation), and duration of stay in post anesthesia care unit (PACU), will be used as secondary outcome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

DOUBLE

Enrollment

Conditions

Muscle Relaxation

Interventions

SugammadexDRUG

sugammadex given based on 3 measurements of body weights

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients older than 18 years and under 45 years, * body mass index ≥ 40 kg/m2, with indication of bariatric surgery Exclusion Criteria: * Patients with comorbid including: neuromuscular disease, renal impairment, and patients with difficult airway were excluded from this study.

Locations (1)

Faculty of Medicine, Ain Shams University

Cairo, Egypt

Outcomes

Primary Outcomes

Reversal Time

Reversal Time: time from administration of Sugammadex to train of four (TOF) ratio ≥ 0.9 will be used as primary outcome.

Time frame: 5 minutes after sugammadex administration

Secondary Outcomes

duration of stay in PACU

period of stay in the PACU

Time frame: 60 minutes after admission to the PACU

Time need for Extubation

time from administration of sugammadex to extubation

Time frame: 10 minutes after sugammadex administration

Data from ClinicalTrials.gov

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