This study investigates the absorption, metabolism, and excretion and the absolute bioavailability of YH12852 in healthy male subjects
Part 1 : Investigate the absorption metabolism, and excretion of YH12852 after single oral administration of YH12852 and 14C-labeled YH12852. Part 2 : Investigate the absolute bioavailability of YH12852 after single oral administration of YH12852 followed by a single i.v. administration of 14C-labeled YH12852.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
10
YH12852 administration
14C-labeled YH12852 administration
Seoul National University Hospital Clinical Trial Center
Seoul, South Korea
Total radioactivity
Total radioactivity recovered
Time frame: 0 - 288 hours (post-dose)
Cmax of YH12852
Peak concentration of YH12852
Time frame: 0(pre-dose), 1, 2, 3, 4, 5, 6, 8, 10, 12, 14, 24, 36, 48, 72, 96, 120, 144, 168, 192, 216, 240, 264, 288 hours (post-dose)
AUClast of YH12852
Area under the concentration-time curve from time 0 to the last measurable time of YH12852
Time frame: 0(pre-dose), 1, 2, 3, 4, 5, 6, 8, 10, 12, 14, 24, 36, 48, 72, 96, 120, 144, 168, 192, 216, 240, 264, 288 hours (post-dose)
Fpo of YH12852
Oral bioavailability of YH12852
Time frame: 0(pre-dose), 1, 2, 3, 4, 5, 6, 8, 10, 12, 14, 24, 36, 48, 72, 96, 120, 144, 168, 192, 216, 240, 264, 288 hours (post-dose)
Aef of YH12852
Amount excreted in feces of YH12852
Time frame: 0 - 288 hours (post-dose)
Aeu of YH12852
Amount excreted in urine of YH12852
Time frame: 0 - 288 hours (post-dose)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.