Human Amniotic Epithelial Stem Cell in Treatment of Refractory Severe Intrauterine Adhesion

Inclusion Criteria: * 1\. Previously diagnosed as uterine adhesion, after the operation of TCRA and the postoperatively standardized hormonal replacement therapy(HRT) , recently diagnosed with refractory Asherman's syndrome or endometrial atrophy(EA); * 2\. According to the American Fertility Society(AFS) classification in 1988, patients are diagnosed of AS or EA stageⅢ-Ⅳ confirmed by hysteroscopy; * 3\. Elimination of infertility, recurrent spontaneous abortion or hypomenorrhea caused by other diseases; * 4\. Be willing to maintain an HRT cycle medication throughout the study, unless it is not tolerated; * 5\. Normal blood coagulation, liver, heart, and kidney function, absence of HIV, Hepatitis B or C, syphilis and psychiatric pathology; * 6\. Be willing to complete the study and sign the consent form. Exclusion Criteria: * 1\. Patients with severe internal disease; * 2\. The patients are suffering from gynecologic inflammation or active genital tubercle bacillus; * 3\. The patient has other uterine diseases or the abnormal uterine cavity which can't be restored by surgery; * 4\. Infertility due to a man's cause; * 5\. The patient has a previous history of cancer and is undergoing radiotherapy or chemotherapy; * 6\. HIV positive * 7\. Active hepatitis B or C infection, syphilis seropositive * 8\. Laboratory routine check index abnormality, such as Hb（hemoglobin）\<8.0 g/dL,WBC（white blood cell count）\<3,000/ml, platelet counts\<75 000/mm3, AST（glutamic oxalacetic transaminase）\>ULN（upper limit of normal），ALT（Glutamic pyruvic transaminase）\>ULN and so on; * 9\. Patients have any complications that may interfere with safety or efficacy or predict life expectancy of less than 24 months; * 10\. Mental illness in the past 6 months; * 11\. Patients have a history of drug or alcohol abuse or dependence in the past two years; * 12\. Unable or unwilling to give informed consent.