This is a prospective, interventional study administering 2 doses of the experimental vaccine (CMV-MVA Triplex) to 20 evaluable patients (10 CMV-seropositive and 10 seronegative) undergoing autologous hematopoietic cell transplantation (HCT) for lymphoma or myeloma on days 28 and 56 post-HCT. The absolute number of adaptive NK cells (CD56dimCD57+NKG2C+) at various days will be compared.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
28
* CMV-MVA Triplex vaccine administered on days 28 and 56 post-HCT * TDap administered on Day 56
Masonic Cancer Center at University of Minnesota
Minneapolis, Minnesota, United States
Change in the absolute number of CMV-induced adaptive NK cells (CD56dimCD57+NKG2C+) between days 28 and 100 post-auto-HCT in patients with lymphoid malignancies.
Change in the absolute number of CMV-induced adaptive NK cells (CD56dimCD57+NKG2C+) on day 28 (pre first vaccine) and day 100 (\~1 month after second vaccine) post-auto- HCT in patients with lymphoid malignancies.
Time frame: Day 28 and Day 100
Change in absolute Number of CMV-induced adaptive NK Cells
Change in absolute number of total NK and NK/T cells between days 28 (first vaccine) and day 100 (\~1 month after second vaccine) post-auto-HCT in patients with lymphoid malignancies (lymphoma and myeloma).
Time frame: Day 28 and Day 100
Response to CMV-MVA Triplex vaccine in CMV seropositive vs. seronegative patients
Change in the absolute number of adaptive NK cells between day 28 post-transplant and day 100.
Time frame: Day 28 and Day 100
Progression Free Survival (PFS)
Incidence of progression-free survival at 1 year in patients receiving CMV-MVA Triplex vaccine with historical controls
Time frame: 1 Year
Response to CMV-MVA Triplex vaccine in lymphoma vs. myeloma patients
Change in the absolute number of adaptive NK cells between day 28 post-transplant and day 100.
Time frame: Day 28 and Day 100
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