Phase 1 Study for Safety and Tolerability of IL-1-Ra Topically Administered to Eyes of Healthy Adult Subjects

Inclusion Criteria: * Healthy adult males and/or females between the ages of 18 and 45 years * Medically healthy * Best correction vision of greater than or equal to 20/20 in each eye * BMI ≥ 19 and \< 24 kg/m2 * Ability to understand and provide informed consent to participate in this study * Willingness to follow study instructions and likely to complete all required visits Exclusion Criteria: * Any ocular or systemic diseases * History of skin or ocular allergy symptoms * Use contact lenses during the trails. * Taking inhaled or oral steroids (for example Advair, Orapred) * Have an active infection * Have serologic evidence of HIV, Hepatitis C, Hepatitis C, or tuberculosis * Receipt of any blood or blood products within 2 months prior to the first dosing day. * Use any drugs within 2 weeks prior to the first dosing day. * Use of cyclosporine, steroid eye drops, serum eye drops, or any other eye medication or experimental drug within the past 4 weeks. * Have been exposed to an investigational drug/device within the preceding 3 months * Pregnant or lactating females * History of substance abuse, drug addiction or alcoholism * Males and females unwilling to use an acceptable method of contraception for the duration of the study