Tramadol is widely used as analgesic in trauma patients. However, it causes side effects, most notably nausea and vomiting. This study aim to determine the role of prophylactic metoclopramide in preventing tramadol induced nausea and vomiting.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
191
One dose of intravenous tramadol 50mg
One dose of intravenous metoclopramide 10mg
Sodium chloride 0.9%
Sarawak General Hospital
Kuching, Sarawak, Malaysia
Nausea severity scale
Change in rating of nausea severity on Visual Analogue Scale 60 minutes after administration of the study drugs. VAS is a standard 100mm line marked "no nausea" at the left end and "worst nausea imaginable" at the right end. Minimum clinically significant difference is defined for this study as 20 mm increment.
Time frame: One hour
Vomiting
Number of episodes of vomiting 60 minutes after administration of study drugs
Time frame: One hour
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