The purpose of this study was to evaluate and compare the plasma pharmacokinetic profiles of ACH-0144471 (danicopan) in healthy participants after administration of single oral doses of modified release prototype formulations.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
14
Danicopan (400 milligrams \[mg\]) oral tablet.
Danicopan (400 mg) oral tablet.
Danicopan (800 mg) oral tablet.
Clinical Trial Site
Ruddington, Nottingham, United Kingdom
Time To Maximum Observed Concentration (Tmax) Of Danicopan After Treatment With Each Prototype Formulation
Time frame: Up to 72 hours postdose
Maximum Observed Concentration (Cmax) Of Danicopan After Treatment With Each Prototype Formulation
Time frame: Up to 72 hours postdose
Area Under The Concentration Versus Time Curve From Time 0 Extrapolated To Infinity (AUC0-inf) Of Danicopan After Treatment With Each Prototype Formulation
Time frame: Up to 72 hours postdose
Participants Experiencing Treatment-emergent Adverse Events
Time frame: Day 1 (postdose) through follow-up visit (10 [+/- 2] days after last study drug administration)
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