Allogenic Mesenchymal Stem Cell Derived Exosome in Patients With Acute Ischemic Stroke

Inclusion Criteria: * Male or female acute ischemic patients aged 40-80 years with symptoms of acute cerebral infarction of less than 24h from stroke onset. * Patients with infarct size 3\*3 * Patients with a measurable focal neurological that must persist to the time of treatment without clinically meaningful improvement. * Patients must have computerized tomography (CT) and / or magnetic resonance imaging (MRI) compatible with the clinical diagnosis of acute ischemic stroke in the territory of the middle cerebral artery before being included in the study. * Patients must have a score on the NIH Stroke Scale 8-24, and mRS ≤ 1 * Women of childbearing age should have a negative pregnancy test performed prior to inclusion * Obtaining informed consent signed Exclusion Criteria: Comatose patients. * brain tumour, cerebral oedema with compression of ventricles, cerebellar infarction or brainstem, or intraventricular, intracerebral or subarachnoid haemorrhage. * alcohol use Active infectious disease, including HIV, hepatitis B, Hepatitis . * patients with dementia. * Specify clinical conditions * Patients who are participating in another clinical trial. * Inability or unwillingness of individual for giving written informed consent.