The aim of this local NIS(Non-Interventional Study) is to determine the proportion of Belgian patients with a duration of treatment(DoT) to Stivarga of 4 months or more in relation to the total population of Belgian metastatic colorectal cancer(mCRC) patients who were treated with Stivarga between the 1st of July 2015 and 31 July 2017. In addition, this study aims to describe the clinical characteristics of Belgian patients with a short- or long-term DoT to Stivarga.
Study Type
OBSERVATIONAL
Enrollment
76
Antineoplastic agents, protein kinase inhibitor (L01XE21)
Belgium
Multiple Locations, Belgium
Proportion of patients with a DoT to Stivarga of more than 4 months versus total study sample
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017
ECOG performance status (0, 1)
ECOG: Eastern Cooperative Oncology Group
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017
Primary site of disease
Rectum, Left-sided colon, Right-sided colon, Colon and rectum, Transverse, Unknown (in colon)
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017
Tumor resection (yes, no, unknown)
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017
Specific site of metastasis
Lung, Liver, Bone, Extraregional nodes, Peritoneum, Multiple, Unknown
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017
KRAS mutation (yes, no, unknown)
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017
RAS mutation (yes, no, unknown)
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017
BRAF mutation (yes, no, unknown)
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017
Start date of Stivarga treatment
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017
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Number of prior treatment lines for metastatic cancer larger than 3 (yes, no, unknown)
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017
Reason for discontinuation of Stivarga treatment
progression - symptomatic, Progression - radiological, Progression - radiological + symptomatic, Progression - unknown, Intolerability, Death, other, unknown, not applicable
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017
Subsequent mCRC treatment
Chemotherapy IV, Chemotherapy oral, Biologic therapy, Chemotherapy + biologic therapy, BSC, Other, Unknown, Not applicable
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017
Last daily Stivarga dose
80 mg, 120 mg, 160 mg, other, unknown
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017
Duration of treatment (months)
Time frame: Retrospective chart review from 1-Jul-2015 to 1-Dec-2017