Intrathecal Atropine to Prevent Postoperative Nausea and Vomiting

Assiut University120 enrolled

Overview

optimal postoperative pain control with intrathecal morphine, with proper prevention of postoperative nausea and vomiting. Dexamethasone, and or atropine could offer some protection against nausea and vomiting.

One of the gold standards for analgesia following cesarean delivery is intrathecal morphine, which is not devoid of complications namely postoperative nausea and vomiting. We evaluated the antiemetic effect of intravenous dexamethasone combined with intrathecal atropine after cesarean delivery under spinal bupivacaine plus morphine anesthesia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

120

Conditions

Postoperative Nausea

Interventions

Intrathecal atropineDRUG

100ug intrathecal atropine will be injected with spinal anesthesia

dexamethasoneDRUG

intravenous 8 mg dexamethasone (2ml).

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * females * 18-40 years of age * elective cesarean delivery under bupivacaine spinal anesthesia Exclusion Criteria: * renal disease * preeclampsia * liver disease * cardiac disease * Coagulopathy * chronic cough * nausea * vomiting * patient refusal

Locations (1)

Emad Zarief Kamel Said

Asyut, Egypt

Outcomes

Primary Outcomes

postoperative nausea

Monitoring scale of nausea and vomiting

Time frame: 24 hours

Data from ClinicalTrials.gov

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