Evaluation of Plant-based Nutritional Products on Stem Cells

Natural Immune Systems Inc24 enrolled

Overview

The purpose of this clinical study is to evaluate acute effects of plant-based nutritional extracts on adult stem cells, using a randomized double-blinded placebo-controlled cross-over study design.

The purpose of this clinical study is to evaluate acute effects of plant-based nutritional extracts on adult stem cells, using a randomized double-blinded placebo-controlled cross-over study design. The research involves testing of acute effects of single doses of antioxidant-rich berry-based extracts, compared to a placebo. Blood samples are taken at baseline and 1 and 2 hours after consuming a single dose. The blood will be used to measure the numbers of different types of stem cells, to evaluate potential effects of stem cell mobilization and homing after consuming plant-based extracts. Adult stem cells are a type of cells that play a role in repairing and rejuvenating various tissue and organs in the body. At NIS Labs, we have shown that many types of plant-based nutritional products have small but reproducible and significant effects on stem cells, cytokines, and regenerative growth factors.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Stem Cell Mobilization Hematopoietic Stem Cell Mobilization Stem Cell Homing

Interventions

Berry extract IOTHER

Seabuckthorn berry proanthocyanidin extract 250 mg single dose

Berry Extract IIOTHER

Seabuckthorn berry proanthocyanidin extract 500 mg single dose

Berry extract blendOTHER

Seabuckthorn berry blend with other berry-based antioxidants

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy adults 20-75 years of age; * Body weight higher than 110 pounds; * BMI below 35; Exclusion Criteria: * Previous major gastrointestinal surgery (absorption of test product may be altered) (minor surgery not a problem); * Currently taking daily OTC medications, such as NSAIDs, Tylenol, allergy medications, and others (birth control and 81 mg aspirin not a problem); * Taking medications that affect the mind (such as anti-depressants) or nervous system (such as gabapentin); * Currently experiencing intense stressful events and life changes; * Actively depressed; * Experiencing sleep disturbances; * Working night shift; * Pregnant, nursing, or trying to become pregnant; * Food intolerances or allergies currently causing discomfort (such as Celiac's disease), due to ongoing inflammatory reactions that may negatively affect product absorption within the 3 hours of testing; * Food allergies related to ingredients in test product.

Locations (1)

Natural Immune Systems

Klamath Falls, Oregon, United States

RECRUITING