The changes in bladder function after the injection of Onabotulinum toxin into the detrusor in individuals with neurogenic bladder overactivity will be investigated retrospectively. The records of all patients treated with Onabotulinum toxin injections into the detrusor since 2000 will be evaluated. The changes in the urodynamic values after the injection of 300 units of Onabotulinum toxin will be compared with the changes after the injection of 200 units. Furthermore, the differences in urinary continence, duration between injections, side effects and complications between the two groups will be investigated.
Study Type
OBSERVATIONAL
Enrollment
56
multiple injections of Onabotulinum toxin into the detrusor muscle
Swiss Paraplegic Centre
Nottwil, Canton of Lucerne, Switzerland
change in detrusor pressure post-injection
bladder detrusor pressure during storage phase
Time frame: within 3 months before injection; within 2 months after injection
maximum bladder volume
Time frame: within 3 months before injection; within 2 months after injection
bladder compliance
The relationship between a change in bladder volume and the change in detrusor pressure (ΔDV/ΔDP).
Time frame: within 3 months before injection; within 2 months after injection
reflexive bladder volume
Time frame: within 3 months before injection; within 2 months after injection
complications
Time frame: within 2 months after injection
presence of urinary incontinence
Time frame: within 3 months before injection; within 2 months after injection
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