Aim of study: To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.
Serum AMH has shown to have a high predictive capability of the ovarian response to stimulation for IVF. On the other hand, patients who are carriers of polymorphisms in the FSH and LH receptors, have shown to need higher doses of gonadotrophins for ovarian stimulation. The proportion of carriers has been described to be around 20% of the population. Nevertheless, the determination of these polymorphisms is not performed in routine practice. It is unknown if their presence affects to the relationship between serum AMH levels and ovarian response. This is a prospective, single center, non-interventional, cohorts study.
Study Type
OBSERVATIONAL
Enrollment
296
Valencian Institute of Infertility, IVI RMA. Valencia
Valencia, Spain
Gonadotrophin receptor polymorphisms and ovarian response and AMH value
To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.
Time frame: 1 year
polymorphisms in the FSH receptor (FSHR) variant N680S
To define the incidence of carriers of polymorphisms in the FSH receptor (FSHR) variant N680S (homozygous and heterozygous) among women undergoing ovarian stimulation for IVF.
Time frame: 1 year
polymorphisms in the LH receptor (LHR) variant N312S
To define the incidence of carriers of polymorphisms in the LH receptor (LHR) variant N312S (homozygous and heterozygous) among women undergoing ovarian stimulation for IVF.
Time frame: 1 year
Doses of gonadotrophin needed and polymorphisms
To analyse the doses of gonadotrophins needed for stimulation on each group of patients
Time frame: 1 year
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