The purpose of this study is to evaluate the effect of probiotics on the gut microbiome of infants treated with antibiotics.
This study aims to examin the impact of probiotics under 2 separate conditions, probiotics concurrent administration with antibiotic and probiotics administration during the recovery phase.Birth,7 days,14 days(or 21 days) and 42 days data will be collected and put into analysis to provide somes suggestions on the probiotics use in the clinical for the infants treated with antibiotics.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
30
the patients in this arm will receive probiotics blend of Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis with does of 1.5\*10\^7CFU for 2 weeks
Shanghai 10th People's Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGchange from birth,7 days,14 days(or 21 days) on gut mcrobiome at 42 days
change of the gut mcrobiome will be calculated at 42 days in comparison with birth,7 days,14 days(or 21 days)
Time frame: 42 days
change from birth on gut mcrobiome at 7 days
change of the gut mcrobiome will be calculated at 7 days in comparison with baseline
Time frame: 7 days
change from birth and 7 days on gut mcrobiome at 14 days(or 21 days)
change of the gut mcrobiome will be calculated at 14(or 21 days) in comparison with birth and 7 days
Time frame: 14 days（or 21days）
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