Pediatric obesity has been increasing in prevalence, but concerns have been raised around the world because no treatment has been found. Recently, however, research on gut microbiome has begun to become a new alternative. It has been shown that changes in the microbiome in adults may induce obesity. However, the results on children are still scarce. Unlike adults, children have few external factors such as alcohol, tobacco, stress, and cancer, making them suitable for obesity-related gut microbiome studies. The investigators will use Illumina MiSeq platform for 16s rRNA metagenomics profiling in children. In this study, the investigators aimed to analyze the relationship between pediatric obesity, gut microbiome profile, blood biomarkers relevant to metabolic syndrome, and nutrient intake data.
Study Type
OBSERVATIONAL
Enrollment
61
Gut microbial profiling will be done with next-generation sequencing targeting bacterial 16s rRNA genes.
Hallym University Kangnam Sacred Heart Hospital
Seoul, South Korea
Correlation of fecal microbial profile with childhood obesity
Analysis of fecal microbial profile using 16s rRNA sequencing
Time frame: visit 1day
Correlation of fecal microbial profile with nutrient intake data using feeding diary
Nutritional intake analysis of total calorie, carbohydrate, fiber, fat, and protein from feeding dairy for two days
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Correlation of childhood obesity with metabolic abnomalities using blood sampling
Glucose, AST, ALT, uric acid, triglyceride, HDL-cholesterol, LDL-cholesterol, total cholesterol, insulin, hsCRP, 25(OH)-Vitamin D3, hemoglobin, ferritin, and HbA1c
Time frame: visit 1day
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