High Throughput Drug Sensitivity and Genomics Data in Developing Individualized Treatment in Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia

Inclusion Criteria: * Diagnosis of multiple myeloma or plasma cell leukemia with documented relapsed or refractory disease according to International Myeloma Working Group (IMWG) criteria, in any one of the following categories: * 3 prior lines of therapy including an immunomodulatory drug (IMiD) and a proteasome inhibitor (PI) * Less than a very good partial response (VGPR) to initial therapy * Early relapse (\< 12 months) after autologous hematopoietic cell transplant (HCT) or after 1st line of therapy * Collection of a bone marrow, fluid or tissue sample that is expected to have enough cells to run the assay * Measurable disease defined by one of the following: * Serum monoclonal protein \>= 0.5 g/dL by serum protein electrophoresis (SPEP) * \>= 200 mg/monoclonal protein in urine on 24 hr urine protein electrophoresis (UPEP) * Involved serum free light chain (FLC) \>= 10 mg/dL and abnormal involved:uninvolved ratio * Plasma cytomas that are palpable per exam or measurable per standard radiologic review * Circulating plasma cells \>= 2,000 if diagnosis of plasma cell leukemia * Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-3 * Female patients of child bearing potential and non-vasectomized male patients agree to practice appropriate methods of birth control * Ability to understand purpose and risks of the study and provide signed and dated informed consent, and authorization to use protected health information * Expected survival is \> 100 days * Adequate organ function as determined by the investigator Exclusion Criteria: * Mucosal or internal bleeding, or platelet transfusion refractory * Any medical conditions that would impose excessive risk to the patient, or would adversely affect his/her participation in the study * Known active infection requiring antibiotics within 7 days of initiation of study treatment, unless considered controlled in the opinion of the investigator * Other malignancy with life expectancy \< 1 year due to the other malignancy * Pregnant or breast feeding women * Serious psychiatric illness, alcoholism, or drug addiction * Human immunodeficiency virus (HIV), or active hepatitis B or C infection * Previous treatments for multiple myeloma (MM) within 2 weeks of initiation of study treatment * Prior autologous or allogeneic stem cell transplantation (SCT) within 12 weeks of initiation of study treatment * Prior allogeneic hematopoietic cell transplantation (HCT) with active graft versus host disease (GVHD) on therapeutic dosing of immunosuppression or prednisone \> 20 mg daily equivalent * Prior major surgical procedure or radiation treatment within 2 weeks of initiation of study treatment (not including limited radiation used for palliation of bone pain)