Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Stroke

Samsung Medical Center43 enrolled

Overview

Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of stroke patients' motor function by altering the cortical excitability. Recently, more challenging approaches, such as stimulation of two or more sites or use of dual modality have been studied in stroke patients. In this study, simultaneous stimulation using both inhibitory rTMS (1Hz) and anodal tDCS (dual-mode stimulation) over bilateral primary motor cortices (M1s) was investigated to compare its modulatory effects with single inhibitory rTMS stimulation in subacute stroke patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Stroke

Interventions

Dual-mode stimulationDEVICE

1Hz rTMS over contralesional primary motor cortex and anodal tDCS over ipsilesional primary motor cortex are simultaneously simulated.

Single sham stimulationDEVICE

1Hz rTMS over contralesional primary motor cortex and sham tDCS (no stimulation) over ipsilesional primary motor cortex are simultaneously simulated.

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * First-ever stroke patients * Subacute stage (less than 4 weeks) * Total Fugl-Meyer Assessment (FMA) score under 84 Exclusion Criteria: * Major active neurological disease or psychiatric disease * A history of seizure * Metallic implants in their brain

Locations (1)

Samsung Medical Center

Seoul, South Korea

Outcomes

Primary Outcomes

Fugl-Meyer Assessment score

Fugl-Meyer Assessment score reflects a motor impairment of a patient. Score range is between 0 and 100.

Time frame: 2 months post-stimulation

Data from ClinicalTrials.gov

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