Release of Proinflammatory Cytokines (IL-1β, IL-6) and Total-prostaglandin (PG) Following Femtosecond Laser-assisted Cataract Surgery Compared to Manual Cataract Surgery

Medical University of Vienna40 enrolled

Overview

Patients with bilateral age related cataract will be included in the study. Manual cataract surgery (MCS) will be performed in one eye and laser cataract surgery (LCS) in the corresponding eye. LCS will be performed with an approved femtosecond laser (FSL) device with an integrated imaging system. After surgery aqueous humour will be collected and screened with Enzyme-linked Immunosorbent Assay (ELISA) Kits for Interleukin-1β; Interleukin-6 and PG.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Age Related Cataracts

Interventions

Femtosecond Laser-assisted

Eligibility

Sex: ALLMin age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Bilateral age-related cataract necessitating phacoemulsification extraction and posterior intraocular lens implantation. * Pupil dilation of ≥ 6.5mm * Age 40 and older Exclusion Criteria: * Corneal abnormality * Pseudoexfoliation * Preceding ocular surgery or trauma * Uncontrolled glaucoma * Proliferative diabetic retinopathy * Iris neovascularization * History of uveitis/iritis * Microphthalmus * Recurrent intraocular inflammation of unknown etiology * Blind fellow eye * Uncontrolled systemic or ocular disease * Pregnancy * Lactation

Outcomes

Primary Outcomes

Proinflammatory cytokines (IL-1β, IL-6) and total-PG

Interleukin IL-1β, Interleukin IL-6, total-prostaglandin

Time frame: 5 minutes after laser procedure