LRTI (Lower respiratory tract infection) is a severe disease in China. The fast and accurate diagnosis of pathogens, bacteria or viruses that cause the infection is critical for the therapy. In this study, investigators assume that the use of FilmArray Respiratory Panel will provide more rapid and comprehensive evidences to physicians to diagnose LRTI which is caused by viruses or atypical pathogens and then reduce the length of antibiotics use by 0.5-1.0 days as well as other hospital resources (length of hospital/ICU stay, take-away oral antibiotics, etc.). Secondly, investigators assume that in LRTI patients with viral infection and a low serum PCT level, fewer length of antibiotics use can be expected. Thirdly, the use of FilmArray Respiratory Panel will provide clearer epidemiology data of virus and atypical pathogens in hospitalized LRTI patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
800
An Multi-PCR method which can detect 20 pathogens in 45 minutes.
Chian Japan Friendship Hospital
Beijing, Beijing Municipality, China
RECRUITINGThe length (days) of antibiotics therapy in hospital between two groups.
The duration of antibiotics used is defined as days of intravenous antibiotic therapy in which any doses of antibiotics are administered.
Time frame: From in-hospital to discharge or death, whichever came first, assessed up to 12 months
Antibiotics therapy cost
Time frame: From in-hospital to discharge or death, whichever came first, assessed up to 12 months
Length of hospital stay (LOS) and/or ICU stay
Time frame: From in-hospital to discharge or death, whichever came first, assessed up to 12 months
The correlation between the initial serum PCT level and clinical outcomes/mortality
Time frame: From in-hospital to discharge or death, whichever came first, assessed up to 12 months
The detection rate of viruses and atypical pathogens by FilmArray in LRTI patients
Time frame: From in-hospital to discharge or death, whichever came first, assessed up to 12 months
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