Efficacy of Low Dose Levothyroxine During Pregnancy

Ain Shams University180 enrolled

Overview

the effect using low dose levo thyroxine in pregnant females with TSH level more than 2.5 mU/L in the first trimester on pregnancy outcome

the study aim to detect the effect of low dose levothyroxine 50 ug on pregnant females and compare it with others receiving placebo

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

180

Conditions

Euthyroid Females

Interventions

levothyroxinDRUG

90 female received levothroxine

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * females with TSH more than 2.5 mU/L and less than 4 mU/L after biochemical diagnosis of pregnancy. Exclusion Criteria: * associated endocrinopathies (PCO/ DM/ hyperprolactinemia ) * associated medical condition (HTN/ chronic kidney disease. * history of recurrent pregnancy loss

Locations (1)

AinShams university maternity hospital

Cairo, Abbassya, Egypt

Outcomes

Primary Outcomes

1st trimester miscarriage

1st trimester spontaneous or missed abortion

Time frame: during 1st 13 weeks of pregnancy

Secondary Outcomes

adverse pregnancy outcome

2nd trimesteric missed or spontaneous abortion ,gestational hypertension,preeclampsia, anemia, abruptio placenta premature delivery , fetal growth restriction, low birth weight

Time frame: last 26 week of gestation

Data from ClinicalTrials.gov

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