Comparing Postoperative Pain Following COX-2 and Prostanoids Expression

Inclusion Criteria: * Female, Age ≥ 20 years * Patients with benign female genital disease who need laparoscopic surgery * Patients with benign disease who can be treated by single port laparoscopy * Patients who signed an approved informed consent Exclusion Criteria: * Female, Age \< 20 years * Pregnancy * Previous cancer history * Patients who refuse to sign an informed consent * Patients with benign female genital disease combined clinical peritonitis (ex. tubo-ovarian abscess, tubo-ovaritis, ruptured endometriosis) * Patients with malignant female genital disease * Patients who got surgery with multi-port laparoscopy * Patients who are contraindicated with COX-2 inhibitors (liver disease, renal disease, active peptic ulcer, active gastrointestinal tract bleeding, ischemic heart disease, hyperkalemia)