Cardiovascular diseases are the most common cause of death in the western world. Myocardial infarction pathogenesis usually involves the development of an atherosclerotic plaque and thrombus. Past research has shown a correlation between thrombin generation values and ischemic heart disease, however, to our knowledge no investigation has been done into the correlation of thrombin generation and cardiac catheterization results in ischemic heart disease patients. In the current research the investigator will investigate the correlation of thrombin generation values using calibrated automated thrombogram and cardiac catheterization results in active ischemic heart disease patients.
The aim of our study is to investigate the correlation of thrombin generation values using calibrated automated thrombogram and cardiac catheterization results in active ischemic heart disease patients. In total 340 patients are planned for inclusion in this trial. After signing an informed consent a blood sample will be obtained from each participant. the investigators will measure the thrombin generation over time in plasma assessed by the calibrated automated thrombogram (CAT). In addition information about the course and results of cardiac catheterization will be collected.
Study Type
OBSERVATIONAL
Enrollment
128
blood samples will be collected . Thrombin generation in platelet-poor plasma will be measured by means of the Calibrated Automated Thrombogram (CAT).
Hemek medical center
Afula, Israel
significant coronary lesion=>70% stenosis or =>50% stenosis in left main.
coronary arteries significant stenosis evaluated by percutaneous coronary intervention in ischemic heart disease patients
Time frame: 1 week
syntax score.
coronary arteries significant stenosis evaluated by percutaneous coronary intervention in ischemic heart disease patients
Time frame: 1 week
The number of stenotic coronary arteries
the number of stenotic vessels in ischemic heart disease patients
Time frame: 1 week
Major adverse cardiac events (MACE)
MACE include acute coronary syndrome, cerebral vascular accident , revascularization, death from any cause
Time frame: 1 year
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