PET/MRI for the Staging of Newly Diagnosed Prostate Cancer

Inclusion Criteria * Patients must have a biopsy-proven diagnosis of high risk, very high risk, or locally advanced prostate cancer * Patients must have a diagnosis of high risk, very high risk, or locally advanced prostate cancer per NCCN Guidelines (T3-T4 disease) * Patients are healthy enough to be deemed surgical candidates with an ECOG performance status of 0-2 * Patients must be age ≥ 18 years * Patients must agree to use adequate contraception (e.g. barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 30 days following completion of the imaging * Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Exclusion Criteria * Patients who have contraindications to MRI (i.e. pacemakers, aneurysm clips or shaped fragments) * Patients who are claustrophobic will be required to take an anti-anxiety medication prescribed by their physician one hour prior to the scan * Patients may not be receiving any other treatments or investigational agents * Patients with a GFR \<30mL/min are ineligible to receive intravenous contrast per standard MR exclusion criteria * Patients not interested in pursuing surgical intervention for their disease (i.e. refusing treatment or requesting radiation oncology referral) * Patients who have received androgen deprivation therapy or prior surgery for prostate cancer * Patients who report taking multivitamins and/or folate supplements on the day of the scan