The aim of this study is to investigate the changes in glycopeptides of serum immunoglobulin G in patients with acute myocardial infarction and the relationships between its change and prognosis.
Immunoglobin G (IgG), a highly abundant glycoprotein in serum, is known to participate in blood immune responses.It has been an increasing interest in the analysis of the abnormal glycosylation of human lgG in healthy and disease states, such as autoimmune diseases and cancer.However, there is few relevant studies about the changes in glycopeptides of serum immunoglobulin G in patients with acute myocardial infarction. This study was performed for the frst timeto assess the quantitative changes of serum IgG glycosylation in patients with acute myocardial infarction and the relationships between its change and prognosis.
Study Type
OBSERVATIONAL
Enrollment
100
Serum (50 each group) is obtained into ethylenediaminetetraacetic acid（EDTA） tubes from all subjects via antecubital venepuncture.Blood is obtained into ethylenediaminetetraacetic acid（EDTA） tubes from all subjects via antecubital venepuncture to assess the quantitative changes of IgG glycosylation by HPLC-MRM at 0 , 3 and 7 days after admission.
The First Affiliated Hospital of Dalian Medical University
Dalian, China
Serum quantitative determination of lgG
Quantitative measurements the changes of serum IgG glycosylation by HPLC-MRM
Time frame: 12 months
Relationship between the serum hs-CRP and the quantitative level of lgG glycopeptides in peripheral blood.
correlation between the serum hs-CRP and lgG
Time frame: 12 months
MACEs during 12-month follow-up
Association of quantitative level of lgG with prognosis
Time frame: 12 months
The changes of LVEF in two groups
Association of quantitative level of lgG with the changes of cardiac function
Time frame: 12 months
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