This study investigated the effectiveness of a surgeon administered, laparoscopic guided, regional anaesthesia technique.
A prospective, double blind, randomised controlled trial was performed. Consenting patients undergoing laparoscopic cholecystectomy were randomised, by envelope, to a laparoscopic guided 2-point blockade (subcostal transversus abdominis plane and rectus sheath) using either Chirocaine® 2.5mg/ml (LaGRA) or 0.9% Saline (Placebo) after specimen extraction. Primary endpoints were post-operative pain in the first 6 hours. Secondary endpoints were analgesic/anti-emetic usage and day case and re-admission rates. Data was analysed using GraphPad Prism (V7).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
76
Levobupivacaine injection to Transversus abdominis plane and rectus sheath
Saline injection to Transversus abdominis plane and rectus sheath
Post operative pain score
Visual analogue pain scores ranging from 0 to 10
Time frame: 6 hours post operatively
Opioid use
Amount (mg) of opioid medication administered
Time frame: Perioperative period including first 6 hours post operatively
Analgesic use
Type and dose of all non opioid analgesic medications prescribed
Time frame: Perioperative period including first 6 hours post operatively
Readmission rate
Patient readmitted to hospital for any reason
Time frame: 30 days post operative
Daycase rates
Patient that was planned for daycase but admitted overnight
Time frame: Day of surgery
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