Quantification of Nerve Stiffness in Neuropathies

Nantes University Hospital36 enrolled

Overview

This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound shear wave elastography. Patients will be compared with age-matched controls.

The following nerve will be studied bilaterally, in a randomised order: Median, ulnar, Radial, Sciatic and Tibial. Participants will be asked to remain relaxed during elastography measurements.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Chronic Inflammatory Demyelinating Polyneuropathy Charcot-Marie-Tooth Disease, Type IA Anti-MAG Neuropathy

Interventions

elastography measurementsOTHER

elastography measurements

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female aged 18 to 65 * Having social insurance status * Having given informed consent * Diagnostic of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), CMT1a or Anti-MAG (peak immunoglobulin M (IGm)\>15,000 BTU) Exclusion Criteria: For controls: * Person staying in a health or social facility * Person unable to understand the protocol and to respect the modalities * Person deprived of liberty * Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice) * Participation in another biomedical research in progress * Diabetes, history of neuromuscular disease For CIDP: * Person staying in a health or social facility * Person unable to understand the protocol and to respect the modalities * Person deprived of liberty * Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice) * Participation in another biomedical research in progress * MRC score \< 3 For Charcot-Marie-Tooth type 1 (CMT1) and anti-MAG: * Person staying in a health or social facility * Person unable to understand the protocol and to respect the modalities * Person deprived of liberty * Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice) * Participation in another biomedical research in progress

Locations (1)

Univeristy of Nantes

Nantes, France

Outcomes

Primary Outcomes

nerve shear wave velocity

Ultrasound shear wave elastography will provide a measure of nerve shear wave velocity, which will be used as a surrogate of nerve stiffness.

Time frame: Day0

Data from ClinicalTrials.gov

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