Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy. The aim of the present study was to evaluate osteoporosis by using high-resolution peripheral quantitative computed tomography (HR-pQCT) in the long course after gastrectomy. In total gastrectomy and distal gastrectomy groups, at least 5 years should have elapsed since gastrectomy.
The patients after gastrectomy loss appetite and decrease the weight. Total gastrectomy especially cause severe sarcopenia and metabolic change. Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy. The primary tools for assessing volumetric density and bone structure are quantitative computed tomography (QCT) and more recently, high-resolution peripheral quantitative computed tomography (HR-pQCT). However the validation of osteoporosis with HR-pQCT before and after gastrectomy remain elusive. The aim of the present study was to evaluate osteoporosis by using HR-pQCT before and after after endoscopic resection, distal gastrectomy, and total gastrectomy in the patients with gastric cancer.
Study Type
OBSERVATIONAL
Enrollment
42
Nagasaki University Hospital
Nagasaki, Japan
RECRUITINGComparing bone microstructure in control, DG, and TG groups
volumetric bone mineral density loss comparing with before the treatments
Time frame: 2 years after the treatments
Comparing bone microstructure with sarcopenia
Correlation between bone mineral density in HR-pQCT and cross-sectional area of the abdominal psoas major muscle
Time frame: Before the treatments and 1 and 2 years after the treatments
Comparing bone microstructure with serum biomarkers of osteoporosis
Correlation between bone mineral density in HR-pQCT and biomarkers (25-hydroxyvitaminD, calcium, iPTH, P1NP, ICTP, TRACP5b)
Time frame: Before the treatments and 1 and 2 years after the treatments
Comparing bone microstructure with dual-energy X-ray absorptiometry
Correlation of bone mineral density between HR-pQCT and DXA
Time frame: Before the treatments and 1 and 2 years after the treatments
Comparing bone microstructure with quality of life (QOL-C30)
Patients will be asked to complete a short debriefing questionnaire covering questions.(QOL-C30). We compared the average sore about Valid and reliable 30-item questionnaire assessing health related quality of life (6 functional, 9 symptom) before and after treatments. The score about QOL-C30 is evaluated on a four level scale without Global quality of life. Global quality of life is evaluated on a seven level scale.
Time frame: Before the treatments and 1 and 2 years after the treatments
Comparing bone microstructure with quality of life (BDHQ)
Patients will be asked to complete a short debriefing questionnaire covering questions (BDHQ) B-DHQ is 58-item fixed-portion-type questionnaire The score about BDHQ is evaluated on a seven level scale.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: Before the treatments and 1 and 2 years after the treatments
Comparing bone microstructure with quality of life (FRAX)
Patients will be asked to complete a short debriefing questionnaire covering questions (FRAX). FRAX score is 12. FRAX is 12-item fixed-portion-type questionnaire. The score about FRAX is evaluated on a two level scale.
Time frame: Before the treatments and 1 and 2 years after the treatments