Emergence agitation is one of the common postoperative complications after functional endoscopic sinus surgery（FESS). The objective of present study is to explore the effectiveness of butorphanol in the alleviation of emergence agitation in patients undergoing Functional Endoscopic Sinus Surgery.
Butorphanol is a mixed agonist-antagonist opioid with strong κappa-receptor agonist and weak mu-receptor antagonist activity. It is commonly used for the management of cancer, postoperative, gynecologic, and obstetric pain. Additionally, Butorphanol has less respiratory depression and sedation effects, which make it may become a good medicine to alleviate the agitation. However, there is no clinical evidence to confirmation of such effectiveness of butorphanol. The objective of present study is to explore the effectiveness of butorphanol in the alleviation of emergence agitation in patients undergoing Functional Endoscopic Sinus Surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
700
IV injection during induction
IV injection during induction
Renji Hospital, Shanghai Jiao Tong University, School of Medicine
Shanghai, Shanghai Municipality, China
RECRUITINGEmergence agitation incidence
Emergence agitation incidence
Time frame: 1 hour in the post anesthesia care unite(PACU)
MAP
The mean arterial pressure
Time frame: 1 hour in the post anesthesia care unite(PACU)
HR
Heart rate
Time frame: 1 hour in the post anesthesia care unite(PACU)
quality of recovery -40 questionnaire
Measurement of quality of recovery with QoR-40
Time frame: 24h after operation
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