9 Minutes for Colonoscopy Withdrawal

Changhai Hospital1,027 enrolled

Overview

A withdrawal time of at least 6 minutes has been considered to be necessary to guarantee the adenoma detection rate and the critical quality criterion of colonoscopy. However, several large observational investigations demonstrated that 9 minutes will be in favor of higher adenoma detection rate and lower risk of interval colorectal cancer, when compared with 6-minute withdrawal. Meanwhile, a few studies also indicated that no significant benefit were observed in longer withdrawal time. Up to now, no randomized controlled trials have been conducted to give a definitive conclusion. Therefore, we performed a multicenter, prospective, randomized Controlled trial to compare adenoma detection rate of 6-minute and 9-minute withdrawal in colonoscopy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

1,027

Conditions

Colon Polyps Colorectal Adenomas

Interventions

Eligibility

Sex: ALLMin age: 40 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients whose age is between 40-85. * Patients who have indications for screening, surveillance and diagnostic colonoscopy. * Patients who have signed inform consent form Exclusion Criteria: * Patients who have undergone colonic resection * Patients with intracranial and/or central nervous system disease, including cerebral infarction and cerebral hemorrhage. * Patients with severe chronic cardiopulmonary and renal disease. * Patients who are unwilling or unable to consent. * Patients who are not suitable for colonoscopy * Patients who received urgent or therapeutic colonoscopy * Patients with pregnancy, inflammatory bowel disease, polyposis of colon, colorectal cancer, or intestinal obstruction * Patients who are taking aspirin, clopidogrel or other anticoagulants * Patients with Aronchick score \> 3

Outcomes

Primary Outcomes

adenoma detection rate(ADR)

ADR was calculated adenoma detection rate is the number of patients with at least one adenoma, divided by the total number of patients.

Time frame: 30mins

Secondary Outcomes

adenomas per colonoscopy(APC)

APC was calculated as the number of adenomas detected during colonoscopy withdraw divided by the number of colonoscopies.