This prospective cohort study will investigate whether progression of the interstitial lung diseases is related to specific clinical endpoints and their changes over time. Longitudinal data of patients will be compared to an age-matched control group during a follow-up of at least two years.
Study Type
OBSERVATIONAL
Enrollment
105
Objectively measured physical activity using activity monitors.
Assessment of functional exercise capacity.
Assessment of maximal exercise capacity.
Universidade Estadual de Londrina
Londrina, Paraná, Brazil
RECRUITINGChanges of daily steps over time
Changes in daily steps (measured using an activity monitor) at every 6-month interval until study completion or end of participation in the study.
Time frame: from date of inclusion until the date of study completion or until the documented date of death from any cause, whichever came first, up to 48 months
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Assessment of muscle force, muscle endurance and muscle fatigability
Assessment of whole-body plethysmography and spirometry.
Assessment of bioelectrical impedance.
Assessment of Health-related quality of life by the "Saint-George Respiratory questionnaire (SGRQ-I)"
Assessment of symptoms by the "UCSD Short of breath questionnaire"
Assessment of Health-related quality of life by the "SF-36 questionnaire"
Assessment of anxiety and depression by the "Hospital Anxiety And Depression (HADS) Scale"
Assessment of symptoms by the "modified Medical Research Council (mMRC) scale"
Assessment of sleep by the "Pitsburg Sleep Quality Index (PSQI)"
Assessment of sleepiness by the "Epworth Sleepiness Scale"
blood assessment of inflammatory markers: IL-2, IL-10, IL-6, IL-4 e IL-17A, TNF, Interferon-γ, CK and CRP. Blood assessment of oxidative stress: TRAP, SH, SOD, CAT, PON 1, Gpx, MDA, NOx, FOX and AOPP.
Timed-up-and-go at usual pace (TUGu) and at a fast pace (TUGf), four-metre gait speed test (4MGS), sit-to-stand test using three protocols: 30 seconds (30sec-STS), one minute (1min-STS) and five-repetition (5rep-STS) and Short Physical Performance Balance (SPPB).