Enteral nutrition in critically ill patients undergoing vasoactive support due to hemodynamic instability is controversial. Hypothesis: enteral nutrition delivered in such patients can be feasible and safe.
Nutrition support in critically ill patients undergoing vasoactive support due to hemodynamic instability is controversial and challenging. However, if it is delivered according to an enteral nutrition protocol and under proper medical supervision, it can be feasible and safe. The present multicenter prospective study was designed to examine the feasibility and safety of enteral nutrition support in such patients.
Study Type
OBSERVATIONAL
Enrollment
200
Enteral nutrition support
Hospital Regional Universitario de Málaga
Málaga, Andalusia, Spain
Dose of vasoactive drugs.
Dose of vasoactive drugs (highest daily), in μg/kg/min.
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.
Kilocalories delivered by enteral route and Energy balance (Kilocalories delivered by enteral nutrition - (minus) enteral nutrition target in Kilocalories).
Main Enteral nutrition efficacy-related variables. Enteral nutrition target was 25 Kilocalories/Kg, if body mass index (BMI) was between 20 and 30. Corrections were made if BMI was under 20/ or over 30.
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.
Enteral nutrition-related mesenteric ischemia.
Main enteral nutrition- safety related variable, suspected by the presence of warning signs (clinical, analytical, radiological), confirmed by laparotomy/laparoscopy, arteriography or angio-CT.
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.
Blood lactate.
Daily peak blood lactate, in mmol/l.
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.
Cardiac index.
Daily lowest cardiac index, in L/min/m\^2
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.
Mechanical circulatory support.
Dependence on Mechanical circulatory support (intra-aortic balloon pump, mechanical circulatory assistance, or extracorporeal membrane oxygenation).
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Hospital de San Jorge
Huesca, Aragon, Spain
Hospital de Barbastro
Huesca, Aragon, Spain
Hospital Universitario Miguel Servet
Zaragoza, Aragon, Spain
Hospital de Manacor.
Palma de Mallorca, Balearic Islands, Spain
Hospital Universitario Río Hortega
Valladolid, Castille and León, Spain
Hospital Universitario de Bellvitge
Barcelona, Catalonia, Spain
Hospital Universitario Germans Trias i Pujol
Barcelona, Catalonia, Spain
Hospital Universitario de Girona Josep Trueta
Girona, Catalonia, Spain
Hospital Universitario Arnau de Villanova
Lleida, Catalonia, Spain
...and 13 more locations
Time from Intensive Care Unit admission to the start of enteral nutrition.
Time frame in hours from Intensive Care Unit admission to the start of enteral nutrition.
Time frame: Up to 120 hours after Intensive Care Unit Admission.
Nutrition Tolerance.
Kilocalories delivered by enteral nutrition, divided by nutrition target in Kilocalories, expressed as percentage.
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.
High gastric residual volume.
Gastric residual volume was described as high when \>500 mL was obtained in each assessment.
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission
Abdominal distention.
A change in the abdomen detected in a physical examination, with an increase in abdominal cavity size relative to that recorded in the pre-enteral nutrition examination
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.
Regurgitation.
Presence of Enteral nutrition feed in the oral cavity or oropharynx, as well as its spontaneous drainage by the oral and/or nasal route
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.
Enteral nutrition-related diarrhea.
5 or more liquid stools in 24 hours or more than two 1000-mL stool volumes, each deposited over a 24-hour period.
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.
Constipation.
Lack of bowel movements in 7 days from the onset of enteral nutrition or for 3 days in the first week of admission.
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.
Bronchoaspiration.
The presence of respiratory secretions of similar characteristics to the prescribed enteral nutrition feed, confirmed by the glucose-oxidase technique in tracheal secretion.
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.
Nasogastric tube complications.
Obstruction or misplacement/accidental extubation.
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.
Enteral nutrition interruptions.
Need to interrupt or discontinue enteral nutrition (and reasons)
Time frame: Daily to a maximum of 14 days after Intensive Care Unit Admission.