Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.

N/ACompletedNCT03401944

Göteborg University24 enrolled

Overview

The study investigates effects related to muscle protein metabolism at provision of Total Parenteral nutrition.

Randomized study investigating alterations in muscle protein metabolism at provision of parenteral nutrition. The study uses a genomic/transcriptomic/proteomic approach to evaluate factors related to activation of skeletal muscle protein synthesis. Patients scheduled for major gastrointestinal surgery are included. Muscle specimens are collected during surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Wasting;Muscle(S)

Interventions

TPNDRUG

ControlOTHER

Eligibility

Sex: ALLMin age: 20 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Major gastrointestinal surgery * Assumed need of post-operative artificial nutrition. Exclusion Criteria: * Insulin dependent diabetes * Steroid medication

Locations (1)

Department of Surgery

Gothenburg, Sweden

Outcomes

Primary Outcomes

Muscle protein metabolism

Alterations in muscle protein metabolism will be assessed by various standard techniques for gene and protein expression. Combined measurements of cell-signaling molecules representing anabolic and catabolic signaling pathways will be evaluated in relation to transcription of muscle myosin proteins.

Time frame: Single evaluation point at 12-14 hours following the start of overnight infusion.

Data from ClinicalTrials.gov

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