The myopia prevalence in schoolchildren is high in Taiwan. The myopia progression is fast in children and often associated high myopia in later life. This prospective and randomized study to investigate the effect of myopia control in myopic children with ultra low concentrations of atropine eye drops and/or low concentrations of anti-allergic and inflammatory eye drops.
Myopia onset earlier in children who would suffer a high degree of myopia in the future adulthood.and higher risk for retinal detachment, macular degeneration, and even blindness. In Taiwan, myopia macular degeneration is the first place of irreversible blind cause in the elderly. The evidence based medicine shows atropine is the most effective treatment for the progression of myopia so far, but the side effects including photophobia and near blurred vision often disturbing patients and resulting poor compliance and high drop-out rate. Recently, the studies from Taiwan and Singapore showed that low concentrations of atropine (0.05% or 0.01%) can effectively inhibit the myopia progression, reduce the symptoms of photophobia, and to achieve favorable myopia control. Previous study found that myopia and allergic conjunctivitis and inflammation were related. The investigators designed a prospective and randomized study to investigate the effect of myopia control in myopic children with ultra low concentrations of atropine eye drops and/or low concentrations of anti-allergic and inflammatory eye drops. Due to environmental factors such as near work, after school class and outdoor activity are also great associated with myopia, the questionnaires also are collected in this study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
150
children who received daily eye drops for myopia
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
RECRUITINGCycloplegic spherical refraction change measured by auto-refractometer (Diopter)
Cycloplegic spherical refraction change measured by auto-refractometer (Diopter) is the main indicator of the myopia progression.
Time frame: 1 year
Axial length change (mm) measured by non-contact biometry
Axial length change (mm) measured by non-contact biometry is another indicator of the myopia progression.
Time frame: 1 year
Intraocular pressure (mmHg) by non-contact tonometer
measures Intraocular pressure (mmHg) by non-contact tonometer
Time frame: 1 year
Accommodation (diopter) by accommodometer
Accommodation change (diopter) by accommodometer is another indicator of the myopia progression.
Time frame: 1 year
Pupil size (mm) by electronic rule
measures Pupil size (mm) by electronic rule
Time frame: 1 year
Anterior chamber depth (mm) measured by non-contact biometry
measures Anterior chamber depth (mm) measured by non-contact biometry
Time frame: 1 year
Posterior chamber depth (mm) measured by non-contact biometry
measures Posterior chamber depth (mm) measured by non-contact biometry
Time frame: 1 year
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