To investigate the effects of different sedation protocols on skeletal muscle metabolism in mechanical ventilated patients in ICU. Mechanical ventilated patients who are anticipated to stay in ICU for more than 5 days are enrolled and randomly assigned to the following three groups, interventional group(dexmedetomidine), control group(midazolam) and no sedation group. Serum, CT scan of intercostal muscles, ultrasound evaluation of quadriceps femoris are obtained.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
360
consistent infusion at a loading dose of 0.15ug/kg/h, increased by 0.15ug/kg/h, with a maximum dose of 1.5ug/kg/h.
consistent infusion at a loading dose of 1mg/h, increased by 1mg/h, with a maximum dose of 10mg/h.
The Affliated Drum Tower Hospital, Medical School of Nanjing University
Nanjing, Jiangsu, China
RECRUITINGacute muscle wasting
measured by 3-MH release in serum
Time frame: From date of randomization to extubation,up to 7 days
28-day mortality
death rate within 28 days after mechanical ventilation
Time frame: From date of randomization to date of death from any cause,up to 28 days
length of ICU stay
time from enrollment to discharge or die
Time frame: From date of randomization to date of to discharge or death,up to 28 days
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