PET CT Re-Planning NSCLC (4DCT-PET)

University Health Network, Toronto36 enrolled

Overview

This study will see whether the addition of more frequent planning CTs during the course of radiation, and of Positron Emission Tomography (PET), a diagnostic test similar to CT, prior to and during a course of radiation may provide information that could potentially be used during the treatment to improve the initial radiation plan.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Lung Cancer Non-Small Cell Lung Cancer

Interventions

PET/CT ScansDIAGNOSTIC_TEST

PET Imaging requires the use of an investigational drug, a radioactively-labelled sugar called 18F-Fluorodeoxyglucose (FDG). FDG is glucose labelled with a radioactive fluorine atom. It is given by intravenous injection and is particularly absorbed by cancer cells. The radioactive signal given off by the FDG can then be detected by the PET scanner providing an image of the cancer (or tumour).

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age equal to or more than 18 years old * Patients with NSCLC consenting for radiotherapy to the primary tumor and / or mediastinal / hilar lymph nodes. Prescription doses should be 60Gy or higher. * Chemo-RT patients of any stage of NSCLC * Patients with a measurable tumor on CT scan. * Patients who are able to lie supine for two consecutive 25 minutes sessions. Exclusion Criteria: * Trimodality patients who will have surgery within 2 months post RT * Previous radiotherapy to intended treatment volumes. * Patients with recurrent disease * Active malignancy other than lung cancer * Pregnancy * Failure to provide written informed consent

Outcomes

Primary Outcomes

GTV volumes

The ratio of the GTV volumes defined using 4D CT (GTV4DCT) planning scans is a prognostic parameter for NSCLC.

Time frame: 2 weeks post RT treatment

GTV volumes

The ratio of the GTV volumes defined using 4D CT (GTV4DCT) planning scans is a prognostic parameter for NSCLC

Time frame: 4 weeks post RT Treatment

GTV volumes

The ratio of the GTV volumes defined using 4D CT (GTV4DCT) planning scans is a prognostic parameter for NSCLC

Time frame: 7 weeks post RT Treatment

GTV volumes

he ratio of the GTV volumes defined using 4D CT (GTV4DCT) planning scans is a prognostic parameter for NSCLC

Time frame: 3 months post RT treatment

GTV volumes

The ratio of the GTV volumes defined using FDG PET (GTVPET) planning scans

Time frame: 2 weeks post RT Treatment

GTV Volumes

The ratio of the GTV volumes defined using FDG PET (GTVPET) planning scans

Time frame: 4 weeks post RT Treatment

GTV Volumes

The ratio of the GTV volumes defined using FDG PET (GTVPET) planning scans

Time frame: 7 weeks post RT Treatment

GTV volumes

The ratio of the GTV volumes defined using FDG PET (GTVPET) planning scans

Time frame: 3 months post RT treatment

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.