Evaluate the Effects of the Environmental Change in Intestine by Antibiotics on the Pharmacokinetic Characteristics of Simvastatin in Healthy Male Volunteers

Inclusion Criteria: * Age between 19 Y to 50 Y at the screening * Body weight over 55 kg and BMI should be between 18.0 to 25.0 kg/m2 * Informed consent will be taken before all the procedures from volunteers * SLCO1B1 genotype is \*1/\*1 when screening Exclusion Criteria: * No significant disease history or ongoing disease * Allergic to simvastatin and vancomycin, or similar affiliation drug for simvastatin or vancomycin * MDRD eGFR less than 60 mL/min/1.73m2 * Total cholesterol, LDL, TG is higher than 1.5 times more than upper normal limit at the screening * HDL less than 35 mg/dL at the screening * Positive HBV or HIV or HCV * Who is administering or going to administer CYP3A4 inihibitor drug * Other clinically significant situation under doctor's opinion