Kidney Function in Diabetics During CPB (Cardio Pulmonary Bypass)

Sahlgrenska University Hospital30 enrolled

Overview

Filtration of urine in the kidney requires sufficient oxygen supply. The filtration of urine is greater in patents with diabetes. Our theory is that the diabetic kidney has a higher oxygen demand than the non diabetic kidney thereby making the diabetic kidney more sensitive to decreased oxygen delivery following reduced blood flow. With a catheter inserted into the kidney vein we will monitor the blood flow and oxygen saturation before and during CPB, in patient with diabetes.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Diabetes Mellitus, Kidney, CPB

Interventions

DM-ECCDIAGNOSTIC_TEST

Diabetes mellitus CPB

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with diabetes mellitus * Serum creatinine \< 150 micromol/L preoperative * Heart surgery requiring CPB * LV (left ventricle) EF \>40 % * Normal hemoglobin Exclusion Criteria: \-

Locations (1)

Sahlgrenska University Hospital

Gothenburg, Sweden

Outcomes

Primary Outcomes

Renal O2 extraction

Renal O2 extraction measured by sampling blood from a catheter inserted into the kidney vein.

Time frame: 2 years

Secondary Outcomes

GFR

GFR (Glomerular filtration rate), measured with CrEDTA- and PAH- clearance.

Time frame: 2 years

Renal blood flow

Change in renal blood flow measured by sampling blood from a catheter inserted into the kidney vein

Time frame: 2 years

Data from ClinicalTrials.gov

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