Bearers of the sickle cell allele (S) are currently eligible for blood donations in Belgium. As blood donors are not tested for this allele, their heterozygous status is unknown. However, guidelines recommend to transfuse sickle cell patients with blood that is negative for the 'S' hemoglobin. To the investigator's knowledge, no study has been conducted to evaluate the impact of transfusion with blood originating from heterozygous donors on the transfusion performance and the improvement of clinical status of the sickle cell disease patients.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
173
Extra blood samples taken for laboratory analysis
CHU Brugmann
Brussels, Belgium
HUDERF
Brussels, Belgium
Hemoglobin level -patient
Hemoglobin level (g/dL)
Time frame: 1 hour before blood transfusion
Hemoglobin level -patient
Hemoglobin level (g/dL)
Time frame: 1 hour after blood transfusion
% of 'S' type hemoglobin -patient
% of 'S' type hemoglobin (assessed by means of hemoglobin electrophorese)
Time frame: 1 hour before blood transfusion
% of 'S' type hemoglobin -patient
% of 'S' type hemoglobin (assessed by means of hemoglobin electrophorese)
Time frame: 1 hour after blood transfusion
Hemoglobin level - transfused blood
Hemoglobin level (g/dL)
Time frame: 1 hour before blood transfusion
% of 'S' type hemoglobin -transfused blood
% of 'S' type hemoglobin (assessed by means of hemoglobin electrophorese)
Time frame: 1 hour before blood transfusion
Transfusion yield
Computed by means of a formula taking the level of hemoglobin, the % of 'S' type hemoglobin and the body surface into account.
Time frame: 1 hour after blood transfusion
Medical complications
List of medical complications having occured after a surgery. Applicable only to the 'transfusion prior to surgery' groups.
Time frame: 1 month
Length of stay
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Length of stay within the hospital. Applicable only to the 'acute transfusion' groups
Time frame: 1 month
Length of stay post transfusion
Length of stay within the hospital after a blood transfusion. Applicable only to the 'acute transfusion' groups
Time frame: 1 month
Number of blood transfusions
Number of blood transfusions. Applicable only to the 'acute transfusion' groups
Time frame: 1 month
Hospital re-admission
Hospital re-admission. Applicable only to the 'acute transfusion' groups
Time frame: 1 month
Mortality rate
Mortality rate. Applicable only to the 'acute transfusion' groups
Time frame: 1 month.