Intervention cross-over study during which participants receive standardized amounts of aronia berry tablets or placebo for three months, then wash out for three months, then aronia tablets or placebo for three months. The potential health effects are investigated. Following parameters are measured before and after each period of tablet intake: 1) Blood pressure, 2) Lipid fractions, 3) Testosterone, 4) Phase II markers, 5) HbA1c, 6) HSCRP, 7) F2-isoprostanes, and 8) semen quality.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
109
Three tablets three times à day for three months then washout for three months, then three placebo tablets three times à day for three months. Blood samples and semen samples collected before and after each period of tablet intake.
Three tablets three times à day for three months, then washout for three months, then three aronia tablets three times à day for three months. Blood samples and semen samples collected before and after each period of tablet intake.
Centre of Andrology & Fertility Clinic, Department D, Odense University Hospital
Odense, Denmark
Cholesterol
HDL, LDL and total cholesterol in mmol/L
Time frame: 9 months
Phase II enzyme activity
Glutathion in U/mL
Time frame: 9 months
Phase II enzyme activity
Superoxid dismutase (SOD) in U/mL
Time frame: 9 months
Phase II enzyme activity
Catalase (CAT) in U/mL
Time frame: 9 months
Isoprostanes
Peroxidation of fatty acids measured in U/mL
Time frame: 9 months
Semen quality
Sperm count in million/mL
Time frame: 9 months
Semen quality
Motility in percent
Time frame: 9 months
Semen quality
DNA fragmentation in percent
Time frame: 9 months
Blood pressure
Systolic and diastolic blood pressure in mmHg
Time frame: 9 months
High Sensitivity C reactive protein
Acute phase reactant in mg/L
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Time frame: 9 months