Uterine Microbiome in Women with Repeated Implantation Failure and Normal Fertile Women

University Hospital, Ghent13 enrolled

Overview

Characterization of the uterine microbiome in women with repeated implantation failure as well as in normal fertile women.

In the midluteal phase of the cycle, a vaginal swab and endometrial biopsy will be obtained.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Repeated Implantation Failure Normal Fertile

Interventions

Vaginal swab + endometrial biopsyOTHER

In the midluteal phase of the cycle, a vaginal swab (E swab) and endometrial biopsy (TAO brush) will be obtained.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 39 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Women between their 18th and 40th birthdays (max 39 years and 364 days at the day of signing the informed consent) * Able to understand, read and speak Dutch and hence to provide written and oral informed consent * Negative serological tests for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), Rapid plasma reagin (RPR) for syphilis Exclusion Criteria: * Hormonal contraception in current cycle * Presence of intra-uterine device * Antibiotic treatment in the current cycle

Locations (1)

Ghent University Hospital

Ghent, Belgium

Outcomes

Primary Outcomes

Midluteal uterine microbiome profile

Descriptive analysis of the uterine microbiome present

Time frame: 1 week

Secondary Outcomes

Midluteal vaginal microbiome profile

Descriptive analysis of the vaginal microbiome present (quality control of endometrial sampling)

Time frame: 1 week

Data from ClinicalTrials.gov

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